2018/05/22

Healthy ageing of cloned sheep

論文メモというカテゴリーを作りました。未整理、あまり精読してない論文についての覚え書き。情報がまとまってきたら、本家サイトにページを作るかも、という内容。

Healthy ageing of cloned sheep
Nat Commun, 7, 12359, 2016

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クローン羊を使って、核移植が老化に及ぼす影響を調べた論文。有害な影響はみられないという結論。

・ Somatic-cell nuclear transfer (SCNT) で得られた生物に対する初めての長期追跡調査。
・ ドリーを生んだ細胞株から得られた 4 匹を含む、13 匹を対象とした。7-9歳のヒツジ。
・ 血圧、代謝、関節の画像解析など。老化のパターンは、健康な個体と変わらない。
・ テロメア長が短いはず。

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